Poster 2009: Clinical substantiation of immunocorrective therapy in children with atopic dermatitis

Methods 61 children aged 5 to 17 years with AD in remission who received the conventional basic therapy (BT). BT included: elimination of cause significant allergens, use of antiinflammatory (local and systemic) therapy, correction of dysfunctions of the gastrointestinal tract. ASIT was performed during three year by an accelerated scheme for parenteral administration of the house dust mite allergens (2 injections per day with an interval of 6 hours). Children with AD were divided into 2 groups: group 1 (31 patients) against BT received under an accelerated scheme a parenteral ASIT (PASIT) mixture of house dust mite allergens. For treatment of group 2 (30 children) against BT combined immunotherapy (CIT) was used: PASIT with an immune modulator Licopid (IM) by 1 mg for 30 days, first in a dose of 10 mg, followed by 20 mg in a day exchange. The clinical efficacy of PASIT and PASIT+IM was assessed by the SCORAD index and the index of dermatological quality of life (QoL) DSQL in the time course: 1, 3, 6, 12, and 36 months after initiation of therapy. The SCORAD index in the examined groups of children before treatment was 44.71 ± 3.12 points.